Discovery of Dihydro-Alkyloxy-Benzyl-Oxopyrimidines as Promising Anti-Influenza Virus Agents
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چکیده
منابع مشابه
Neuraminidase inhibitors as anti-influenza virus agents.
Influenza virus neuraminidase (NA) catalyses the cleavage of sialic acid residues terminally linked to glycoproteins and glycolipids and plays an important role in the replication of the virus. Recently, several potent NA inhibitors have been synthesized based on the rational design of mimicking the transition state of the sialic acid cleavage. Zanamivir and oseltamivir (GS 4104, the prodrug of...
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ژورنال
عنوان ژورنال: Chemical Biology & Drug Design
سال: 2011
ISSN: 1747-0277
DOI: 10.1111/j.1747-0285.2011.01180.x